Lupus vaccines play an important role in protecting people with lupus from preventable infections. Because lupus and many lupus medications can weaken the immune system, individuals may be more susceptible to serious illness. Vaccination can strengthen protection and reduce complications.
Always speak with your rheumatologist or healthcare provider before receiving any vaccine.
Vaccines Recommended for Most Lupus Patients
The following vaccines are commonly recommended for people living with lupus. Your healthcare provider will tailor recommendations based on age, medications and health status.
Flu Shot (Annual)
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Inactivated flu shot only
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Avoid the live nasal spray
Pneumococcal Vaccines
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Protect against pneumonia and bloodstream infections
COVID-19 Vaccines and Boosters
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Important for immunocompromised individuals
Hepatitis B Vaccine
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Recommended if you are at risk of exposure
HPV Vaccine
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Recommended up to age 26; in some cases up to age 45
Tdap or Td Booster
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Given every 10 years
Shingles Vaccine (Shingrix)
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Recommended for adults 50+ and for adults 18+ who are immunocompromised.
Vaccines Usually Avoided When on Immunosuppressive Medications
Because these vaccines are live, they are often avoided for people taking strong immunosuppression.
Always confirm with your specialist before receiving a live vaccine.
Commonly Avoided Live Vaccines
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MMR (measles, mumps, rubella)
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Varicella (chickenpox)
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Live shingles vaccine (Zostavax – rarely used today)
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Live nasal spray flu vaccine
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Yellow fever vaccine
Timing Tips for People With Lupus
Before Starting Immune-Suppressing Medication
Vaccines work best when given before starting strong immunosuppressive drugs.
If You Are Already on Treatment
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Some vaccines may still help, but your response could be weaker
Medication Adjustments
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In some cases, your doctor may adjust the timing of certain medications to help improve vaccine response
Authors: Daniel Tingey and Doctor Janet Pope
Note: Please consult your healthcare provider or local health authorities for up-to-date vaccine recommendations.